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Loss of appetite and weight loss Insomnia, especially when taken late Dry mouth Increased anxiety or restlessness Nausea during the first weeks of use Appetite suppression Elevated blood pressure and heart rate Nervousness or irritability Difficulty falling asleep Mood swings during the comedown phase When comparing the side-effects of Vyvanse vs Adderall, many clinicians point out that Vyvanse tends to produce fewer spikes in side-effect intensity because of its gradual release